Bastyr Center for Natural Health, Seattle, Washington
Health Information
Overview Health Conditions and Concerns Conditions A-M Conditions N-Z Healthy Lifestyle Tips Bastyr Health-E News News and Events Recommended Reading List Recipes National and Community Resources
Schedule an appointment today
Depression | More Evidence St. Johnís Wort Works for Depression

More Evidence St. Johnís Wort Works for Depression

St. Johnís wort, a popular herbal remedy for depression, is at least as effective as the antidepressant drug paroxetine (Paxil®) and causes fewer side effects, reports the British Medical Journalís online edition (; accessed 02/2005). The results of this study add to the large body of research showing that St. Johnís wort is a safe and effective treatment for mild to moderate depression.

In the new study, 251 people suffering from acute depression were randomly assigned to receive 300 mg of a St. Johnís wort extract three times a day or 20 mg of paroxetine once a day for six weeks. If after two weeks the depression had not improved by at least 20%, the dose of St. Johnís wort or paroxetine was doubled for the remainder of the study. After six weeks of treatment, the depression had resolved in 50% of the participants taking St. Johnís wort and in 35% of those taking paroxetine, a statistically significant difference. A dosage increase was necessary at the two-week point in 57% of the people taking St. Johnís wort and in 48% of those taking paroxetine. The incidence of side effects (mainly gastrointestinal symptoms, fatigue, dizziness, headache, dry mouth, or increased sweating) was 72% higher in the group receiving paroxetine than in the St. Johnís wort group.

Many other studies have shown that St. Johnís wort is significantly more effective than a placebo and at least as effective as certain antidepressant drugs, including fluoxetine (Prozac®) and imipramine. Furthermore, in most of these studies, the herbal remedy was better tolerated than the prescription medication. Despite the strong evidence demonstrating St. Johnís wortís effectiveness, its use as a treatment for depression remains controversial.

The controversy stems mainly from a widely publicized negative report published in 2001 in the Journal of the American Medical Association (2001;285:198Ė86). In that study, although the remission rate was significantly greater with St. Johnís wort than with a placebo, only 14.3% of those who received the herb went into remission, causing the authors of the report to question its efficacy. However, the 4.9% remission rate in the placebo group was far below the placebo response rate seen in other studies of depression, which suggests that many of the participants recruited for this study would have been unlikely to respond to any treatment.

The bulk of the evidence at this time indicates that St. Johnís wort is a safe and effective alternative to antidepressant medications for the treatment of mild or moderate depression, although severe depression does not seem to respond to the herb. As it can interact with a fairly large number of medications, people interested in taking St. Johnís wort should be monitored by a qualified healthcare practitioner.

Alan R. Gaby, MD, an expert in nutritional therapies, testified to the White House Commission on CAM upon request in December 2001. Dr. Gaby served as a member of the Ad-Hoc Advisory Panel of the National Institutes of Health Office of Alternative Medicine. He is the author of Preventing and Reversing Osteoporosis (Prima, 1994), and co-author of The Natural Pharmacy, 2nd Edition (Healthnotes, Three Rivers Press, 1999), the AĖZ Guide to Drug-Herb-Vitamin Interactions (Healthnotes, Three Rivers Press, 1999), Clinical Essentials Volume 1 and 2 (Healthnotes, 2000), and The Patientís Book of Natural Healing (Prima, 1999). A former professor at Bastyr University of Natural Health Sciences, in Kenmore, WA, where he served as the Endowed Professor of Nutrition, Dr. Gaby is the Chief Medical Editor for Healthnotes, Inc.

Copyright © 2005 Healthnotes, Inc. All rights reserved. Republication or redistribution of the Healthnotes® content is expressly prohibited without the prior written consent of Healthnotes, Inc. Healthnotes Newswire is for educational or informational purposes only, and is not intended to diagnose or provide treatment for any condition. If you have any concerns about your own health, you should always consult with a healthcare professional. Healthnotes, Inc. shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. HEALTHNOTES and the Healthnotes logo are registered trademarks of Healthnotes, Inc.

Learn More About It

1 | 2 | 3 | 4 | 5 | 6 | 7 |

Find a Provider

Want to find the provider that's right for you? Learn more about our health care providers.  Ľ

Bastyr Center Disclaimer

The health information contained in this site is not intended as medical advice and should not be considered a substitute for appropriate medical care. Any products mentioned in studies cited in Healthnotes articles are not necessarily endorsed by Bastyr. As with any product, consult with a natural health practitioner to discuss what may be best for you.


Appointments: 206.834.4100
Bastyr Center clinic appointments

Submit a contact request or call us to schedule an appointment Ľ

Bastyr University Clinic in San Diego

Are you looking for Bastyr University Clinic, our new teaching clinic in San Diego? More Ľ

Learn More About Our Services

Natural medicine can treat many types of conditions including:

More treatable health conditions Ľ

Bastyr Center healthcare providers

Interested in finding a provider who's right for you? We recommend that your first visit at BCNH be with a Naturopathic Medicine Provider. »

Home  | Health Information  | Health Care Services  | Our Providers  | Patient Care  | Dispensaries

About BCNH  | Contact Us  | Appointments  | Privacy Policy  | Site Map | Bastyr University